go to symptoms
go to success stories
go to advice
go to voices
go to chat
go to media stories
go to scientific abstracts
go to legal area
go to links
go to panic advice go to site info adverse drug reports rant away the money behind the drug for something different     contact webmaster
  Scientific Lit.  

Here you will find a partial collection of articles dealing with Paxil withdrawal and SSRI discontinuation problems. Note that this secton is only a glimpse into the science behind the problem.

In order to keep this information relevant, I rely heavily on the contributions made by visitors to this site. Should you, therefore, come across any new material, I would greatly appreciate it, if you were to send it my way.


Search Web

en francais
(machine translation)


SSRI discontinuation Articles on the Web
FDA's new label information for Paxil (2002)
Antidepressant discontinuation reactions
Paxil Causes Withdrawal in Infants
Persistent adverse neurological effects following SSRI discontinuation .
Reports of SSRI withdrawal reaction
SSRI Withdrawal Syndrome
Withdrawal symptoms associated with paroxetine discontinuation in a 9-year-old boy

SSRI Discontinuation Syndrome
SSRI Withdrawal Syndrome
Medical Journal list of SSRI Withdrawal Syndrome
Antidepressant Withdrawal
Harvard Mental Health on SSRI withdrawal


Bibliography (up to 2000)
Selective Reuptake Inhibitor Discontinuation Syndrome: A Randomized Clinical Trial - Biological Psychiatry 1998; 44 pp.77-87
A comparison of the post-marketing safety of four selective serotonin re-uptake inhibitors including the investigation of symptoms occurring on withdrawal.Br J Clin Pharmacol. 1996 Dec;42(6):757-63.
A double-blind, randomized study to provide safety information on switching fluoxetine-treated patients to paroxetine without an intervening washout period. J Clin Psychiatry. 1995 Apr;56(4):142-5.
A Comparison of the post marketing safety of four Selective Serotonin Reuptake Inhibitors including the investigation of symptoms occurring on withdrawal - British Journal of Clinical Pharmacology 1996 Dec; 42 (6) pp. 757-763
A possible paroxetine withdrawal syndrome.Am J Psychiatry. 1995 Apr;152(4):645-6.Phillips.
Adverse Effects After the Abrupt Discontinuation of Paroxetine - Pharmacotherapy 15 (6) pp.778-780
Antidepressant Discontinuation Reactions - British Medical Journal 1998 (316) pp.1105-1106 – 11 April
Antidepressant discontinuation: a review of the literature. J Clin Psychiatry. 1997;58 Suppl 7:11-5; discussion 16. Review.
Antidepressant withdrawal syndrome. Br J Psychiatry. 1997 Mar;170:288. No abstract available.
Antidepressant withdrawal syndrome. CNS Drugs. 1996;5:278-292.
Lejoyeux, Adès, Mourad, Solomon, Dilsaver.
Antidepressant withdrawal syndrome.Br J Psychiatry. 1997 ar;170:288 Young, Currie, Ashton.
Antidepressant Withdrawal Syndromes: Phenomenology and Pathophysiology - International Clinical Psychopharmacology 2 p. 1-19

Antidepressant Withdrawal Syndrome: Recognition, Prevention and Management  - CNS Drugs 1996 (5) pp. 278-292

Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning. Eur J Pharmacol. 1995 Mar 6;275(2):185-9.
Discontinuation of antidepressant therapy: emerging complications and their relevance. J Clin Psychiatry. 1998 Oct;59(10):541-8. No abstract available.
Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review. J Clin Psychiatry. 1997 Jul;58(7):291-7. Review.
Discontinuation Symptoms and Psychotropic Drugs - Lancet 2000 v. 355 pp. 1184-1190
Discontinuation symptoms and SSRIs. J Clin Psychiatry. 1998 Oct;59(10):535-7. No abstract available.
Discontinuing antidepressants and benzodiazepines upon becoming pregnant. Bewareof the risks of abrupt discontinuation.Can Fam Physician. 2001 Mar;47:489-90.PMID: 11281079 [PubMed - indexed for MEDLINE]
Adverse events after the abrupt discontinuation of paroxetine. Pharmacotherapy. 1995 Nov-Dec;15(6):778-80.
Hormonal markers of stress response following interruption of selective serotonin reuptake inhibitor treatment. Psychoneuroendocrinology. 2000 Feb;25(2):169-77.
Is there a serotonergic withdrawal syndrome? Biol Psychiatry 1993;33:851-2. Mallya, White, Gunderson.
Lhermitte's sign in paroxetine withdrawal. J Clin Psychopharmacol. 1996 Oct;16(5):411-2. No abstract available.
Medication withdrawal symptoms in obsessive-compulsive disorder patients treated with paroxetine. J Clin Psychopharmacol. 1994 Jun;14(3):206-7. No abstract available.
Michelson D, Fava M, Amsterdam J, Apter J, Londborg P, Tamura R, Tepner RG.Interruption of selective serotonin reuptake inhibitor treatment. Double-blind,placebo-controlled trial.
Br J Psychiatry. 2000 Apr;176:363-8.
Misdiagnosis of antidepressant discontinuation symptoms. Acta Psychiatr Scand. 2000 Dec;102(6):466-7; discussion 467-8. PMID: 11142438 [PubMed - indexed for MEDLINE]
More cases of paroxetine withdrawal syndrome. Br J Psychiatry. 1996 Sep;169(3):384. Pacheco, Malo, Aragues, Etxebeste.
Newer antidepressants and the discontinuation syndrome. J Clin Psychiatry. 1997;58 Suppl 7:17-21; discussion 22. Review.
Newer antidepressants and the discontinuation syndrome. J Clin Psychiatry. 1997;58(suppl 7):17-22. Haddad
Paroxetine discontinuation syndrome in association with sertindole therapy.Br J Psychiatry. 1997 Apr;170:389 Walker-Kinnear, McNaughton.
Paroxetine withdrawal syndrome Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A52-3. French. PMID: 10855379 [PubMed - indexed for MEDLINE]
Paroxetine withdrawal syndrome in a neonate.Br J Psychiatry. 1997 Oct;171:391-2 Dahl, Olhager, Ahlner.
Paroxetine withdrawal syndrome. Am J Psychiatry. 1995 Jan;152(1):149-50 Pyke.
Paroxetine withdrawal syndrome. Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A52-3. Belloeuf, Le Jeunne, Hugues.
Physical symptoms associated with paroxetine discontinuation. Am J Psychiatry. 1994 Feb;151(2):289. No abstract available.
Physical Symptoms associated with Paroxetine Withdrawal - American Journal of Psychiatry 1995; 152 (issue 8) p. 1235
Possible biological mechanisms of the serotonin reuptake inhibitor discontinuation syndrome. J Clin Psychiatry. 1997;58(suppl 7):23-27. Schatzberg, Haddad, Kaplan, Lejoyeux, Rosenbaum, Young, et al.
Postoperative delirium indicating an adverse drug interaction involving theselective serotonin reuptake inhibitor, paroxetine?
J Psychopharmacol. 1999;13(3):313-7.
Potential withdrawal syndrome associated with SSRI discontinuation.
Ann Pharmacother. 1995;29:1284-1285. Lazowick, Levin
Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial.Biol Psychiatry. 1998 Jul 15;44(2):77-87
Rosenbaum, Fava, Hoog, Ascroft, Krebs.
Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria.J Psychiatry Neurosci. 2000 May;25(3):255-61.Black, Shea, Dursun, Kutcher.
Selective serotonin reuptake inhibitor discontinuation syndrome: putative mechanisms and prevention strategies.Can J Psychiatry. 1998 Jun;43(5):523-4.Rojas-Fernandez, Gordon.
Selective serotonin reuptake inhibitor discontinuation syndrome: putative mechanisms and prevention strategies.Can J Psychiatry. 1999 Feb;44(1):95-6.Benazzi.
Serotonin discontinuation syndrome: does it really exist? W V Med J. 2000 Mar-Apr;96(2):405-7. Nuss, Kincaid.
Serotonin reuptake inhibitor withdrawal. J Clin Psychopharmacol. 1996 Oct;16(5):356-62.
Severe psychiatric symptoms associated with paroxetine withdrawal.
Lancet. 1995 Jul 1;346(8966):57. No abstract available.
Severe withdrawal symptoms with fever upon stopping paroxetine.
Ned Tijdschr Geneeskd. 1999 Aug 28;143(35):1795; discussion 1795-6. Dutch. Noabstract available.
Shock-like sensations after discontinuation of selective serotonin reuptake inhibitors. Am J Psychiatry. 1995 May;152(5):810. No abstract available.
SSRI Withdrawal Syndrome 1997, American Society of Consultant Pharmacists, Inc. Skaehill, Welch
SSRI withdrawal.J Clin Psychiatry. 1996 Jul;57(7):310. No abstract available.
The selective serotonin reuptake inhibitor paroxetine is effective in the
treatment of diabetic neuropathy symptoms.Pain. 1990 Aug;42(2):135-44.
Treatment of disequilibrium and nausea in the SRI discontinuation syndrome. J Clin Psychiatry. 1998 Aug;59(8):431-2. No abstract available.
Unilateral facial numbness and visual blurring associated with paroxetine discontinuation. J Clin Psychopharmacol. 2000 Apr;20(2):271-2. No abstract available.
Withdrawal after discontinuation of paroxetine. Aust N Z J Psychiatry. 1996 Oct;30(5):702. No abstract available.
Withdrawal hypomania associated with paroxetine. J Clin Psychopharmacol. 1997 Feb;17(1):60-1. No abstract available.
Withdrawal reactions with selective serotonin re-uptake inhibitors as reported to the WHO system. Eur J Clin Pharmacol. 1997;53(3-4):163-9.
Withdrawal symptoms associated with paroxetine discontinuation in a
nine-year-old boy.J Clin Psychopharmacol. 2000 Oct;20(5):586-7. No abstract available.PMID: 11001250 [PubMed - indexed for MEDLINE]
Withdrawal syndrome after the use of serotonin reuptake inhibitors.
Tidsskr Nor Laegeforen. 2000 Mar 20;120(8):913-4. Norwegian.
Withdrawal syndrome associated with abrupt discontinuation of SSRIs. J Am Pharm Assoc (Wash). 1998 Jul-Aug;38(4):500-1. No abstract available.
Withdrawal syndrome caused by selective serotonin reuptake inhibitors: apropos of a case. Schweiz Rundsch Med Prax. 1998 Mar 4;87(10):345-8. Review. French.
Special thanks to "J.R." , J.B." and E. Silbert for their research



statistics/ Oct. 2002:

visitors: 14 396
visits: 20 958
page views: 82 891



Donations will be used to expand and enhance this site. Please be aware that does not have official charity status. Hence, no tax receipt can be issued.


Canada  come to Nova Scotia
 Site  made in Canada

news | symptoms| success| voices | advice | chat | legal| | links |medical | on panic | about| media| rant| report | financial| the edge |contact
press inquiries |
advertising policy
| © frank streicher 2002