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(researched by J.B)
1993
Is there a serotonergic withdrawal syndrome?
Biol Psychiatry 1993;33:851-2. Mallya, White, Gunderson.
Paroxetine (Paxil) "We have received 78 reports of
symptoms occurring on withdrawal of paroxetine,
including dizziness, sweating, nausea, insomnia, tremor
and confusion. Such reactions have been reported more
often with paroxetine than with other SSRIs. Reactions
tended to start 1-4 days after stopping paroxetine and
in several patients resolved on re-instating treatment.
Paroxetine should not normally be discontinued
abruptly".
1993 Committee on Safety of Medicines & Medicines
Control Agency (Great Britain)
1995
Withdrawal syndromes after paroxetine and seatrain
discontinuation.
J Clin Psychopharmacol. 1995 Oct;15(5):374-5
Fava GA, Grandi S.
A possible paroxetine withdrawal syndrome.
Am J Psychiatry. 1995 Apr;152(4):645-6.
Phillips.
Paroxetine withdrawal syndrome.
Am J Psychiatry. 1995 Jan;152(1):149-50
Pyke.
Potential withdrawal syndrome associated with SSRI
discontinuation.
Ann Pharmacother. 1995;29:1284-1285. Lazowick, Levin.
1996
More cases of paroxetine withdrawal syndrome.
Br J Psychiatry. 1996 Sep;169(3):384.
Pacheco, Malo, Aragues, Etxebeste.
Antidepressant withdrawal syndrome.
CNS Drugs. 1996;5:278-292.
Lejoyeux, Adès, Mourad, Solomon, Dilsaver.
1997
Paroxetine withdrawal syndrome in a neonate.
Br J Psychiatry. 1997 Oct;171:391-2
Dahl, Olhager, Ahlner.
Paroxetine discontinuation syndrome in association
with sertindole therapy.
Br J Psychiatry. 1997 Apr;170:389
Walker-Kinnear, McNaughton.
Antidepressant withdrawal syndrome.
Br J Psychiatry. 1997 Mar;170:288
Young, Currie, Ashton.
Newer antidepressants and the discontinuation
syndrome.
J Clin Psychiatry. 1997;58(suppl 7):17-22. Haddad
Possible biological mechanisms of the serotonin
reuptake inhibitor discontinuation syndrome.
J Clin Psychiatry. 1997;58(suppl 7):23-27. Schatzberg,
Haddad, Kaplan, Lejoyeux, Rosenbaum, Young, et al.
SSRI Withdrawal Syndrome
1997, American Society of Consultant Pharmacists, Inc.
Skaehill, Welch
1998
Treatment of disequilibrium and nausea in the SRI
discontinuation syndrome.
J Clin Psychiatry. 1998 Aug;59(8):431-2
Schechter.
Withdrawal syndrome associated with abrupt
discontinuation of SSRIs.
J Am Pharm Assoc (Wash). 1998 Jul-Aug;38(4):500-1
Wincor.
Selective serotonin reuptake inhibitor
discontinuation syndrome: a randomized clinical trial.
Biol Psychiatry. 1998 Jul 15;44(2):77-87
Rosenbaum, Fava, Hoog, Ascroft, Krebs.
Withdrawal syndrome caused by selective serotonin
reuptake inhibitors.
Schweiz Rundsch Med Prax. 1998;87:345-348
Bryois, Rubin, Zbinden, Baumann.
Selective serotonin reuptake inhibitor
discontinuation syndrome: putative mechanisms and
prevention strategies.
Can J Psychiatry. 1998 Jun;43(5):523-4.
Rojas-Fernandez, Gordon.
1999
Selective serotonin reuptake inhibitor
discontinuation syndrome: putative mechanisms and
prevention strategies.
Can J Psychiatry. 1999 Feb;44(1):95-6.
Benazzi.
2000
Withdrawal syndrome after the use of serotonin
reuptake inhibitors.
Tidsskr Nor Laegeforen. 2000 Mar 20;120(8):913-4.
Fagan.
Serotonin discontinuation syndrome: does it really
exist?
W V Med J. 2000 Mar-Apr;96(2):405-7.
Nuss, Kincaid.
Paroxetine withdrawal syndrome.
Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A52-3.
Belloeuf, Le Jeunne, Hugues.
Selective serotonin reuptake inhibitor
discontinuation syndrome: proposed diagnostic criteria.
J Psychiatry Neurosci. 2000 May;25(3):255-61.
Black, Shea, Dursun, Kutcher.
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Researched
by J.R.
Einarson A, Selby P, Koren G.
Discontinuing antidepressants and benzodiazepines upon becoming pregnant. Beware
of the risks of abrupt discontinuation.
Can Fam Physician. 2001 Mar;47:489-90.
PMID: 11281079 [PubMed - indexed for MEDLINE]
Haddad PM, Qureshi M.
Misdiagnosis of antidepressant discontinuation symptoms.
Acta Psychiatr Scand. 2000 Dec;102(6):466-7; discussion 467-8.
PMID: 11142438 [PubMed - indexed for MEDLINE]
Diler RS, Tamam L, Avci A.
Withdrawal symptoms associated with paroxetine discontinuation in a
nine-year-old boy.
J Clin Psychopharmacol. 2000 Oct;20(5):586-7. No abstract available.
PMID: 11001250 [PubMed - indexed for MEDLINE]
Kirsch MA, Louie AK.
Paroxetine and irritable bowel syndrome.
Am J Psychiatry. 2000 Sep;157(9):1523-4. No abstract available.
PMID: 10964877 [PubMed - indexed for MEDLINE]
Belloeuf L, Le Jeunne C, Hugues FC.
[Paroxetine withdrawal syndrome].
Ann Med Interne (Paris). 2000 Apr;151 Suppl A:A52-3. French.
PMID: 10855379 [PubMed - indexed for MEDLINE]
Michelson D, Fava M, Amsterdam J, Apter J, Londborg P, Tamura R, Tepner RG.
Interruption of selective serotonin reuptake inhibitor treatment. Double-blind,
placebo-controlled trial.
Br J Psychiatry. 2000 Apr;176:363-8.
PMID: 10827885 [PubMed - indexed for MEDLINE]
Fagan M.
[Withdrawal syndrome after the use of serotonin reuptake inhibitors].
Tidsskr Nor Laegeforen. 2000 Mar 20;120(8):913-4. Norwegian.
PMID: 10795494 [PubMed - indexed for MEDLINE]
Nuss S, Kincaid CR.
Serotonin discontinuation syndrome: does it really exist?
W V Med J. 2000 Mar-Apr;96(2):405-7.
PMID: 10771628 [PubMed - indexed for MEDLINE]
Strickland GM, Hough DW.
Unilateral facial numbness and visual blurring associated with paroxetine
discontinuation.
J Clin Psychopharmacol. 2000 Apr;20(2):271-2. No abstract available.
PMID: 10770473 [PubMed - indexed for MEDLINE]
Michelson D, Amsterdam J, Apter J, Fava M, Londborg P, Tamura R, Pagh L.
Hormonal markers of stress response following interruption of selective
serotonin reuptake inhibitor treatment.
Psychoneuroendocrinology. 2000 Feb;25(2):169-77.
PMID: 10674280 [PubMed - indexed for MEDLINE]
Stanford BJ, Stanford SC.
Postoperative delirium indicating an adverse drug interaction involving the
selective serotonin reuptake inhibitor, paroxetine?
J Psychopharmacol. 1999;13(3):313-7.
PMID: 10512094 [PubMed - indexed for MEDLINE]
Bakker A.
[Severe withdrawal symptoms with fever upon stopping paroxetine].
Ned Tijdschr Geneeskd. 1999 Aug 28;143(35):1795; discussion 1795-6. Dutch. No
abstract available.
PMID: 10494333 [PubMed - indexed for MEDLINE]
Vergouwen AC, Kuipers T.
[Severe withdrawal symptoms with fever upon stopping paroxetine].
Ned Tijdschr Geneeskd. 1999 Aug 28;143(35):1794-5; discussion 1795-6. Dutch. No
abstract available.
PMID: 10494332 [PubMed - indexed for MEDLINE]
Peeters FP, Zandbergen J.
[Severe withdrawal symptoms with fever during paroxetine tapering off].
Ned Tijdschr Geneeskd. 1999 Jul 3;143(27):1429-31. Dutch.
PMID: 10422558 [PubMed - indexed for MEDLINE]
Gram LF.
[Withdrawal symptoms in connection with the use of selective serotonin reuptake
inhibitors (SSRI)].
Ugeskr Laeger. 1998 Dec 7;160(50):7291-3. Danish. No abstract available.
PMID: 9859737 [PubMed - indexed for MEDLINE]
Thompson C.
Discontinuation of antidepressant therapy: emerging complications and their
relevance.
J Clin Psychiatry. 1998 Oct;59(10):541-8. No abstract available.
PMID: 9818638 [PubMed - indexed for MEDLINE]
Pollock BG.
Discontinuation symptoms and SSRIs.
J Clin Psychiatry. 1998 Oct;59(10):535-7. No abstract available.
PMID: 9818635 [PubMed - indexed for MEDLINE]
Schechter JO.
Treatment of disequilibrium and nausea in the SRI discontinuation
syndrome.
J Clin Psychiatry. 1998 Aug;59(8):431-2. No abstract available.
PMID: 9721826 [PubMed - indexed for MEDLINE]
Wincor MZ.
Withdrawal syndrome associated with abrupt discontinuation of SSRIs.
J Am Pharm Assoc (Wash). 1998 Jul-Aug;38(4):500-1. No abstract available.
PMID: 9707961 [PubMed - indexed for MEDLINE]
Rosenbaum JF, Fava M, Hoog SL, Ascroft RC, Krebs WB.
Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized
clinical trial.
Biol Psychiatry. 1998 Jul 15;44(2):77-87.
PMID: 9646889 [PubMed - indexed for MEDLINE]
Bryois C, Rubin C, Zbinden JD, Baumann P.
[Withdrawal syndrome caused by selective serotonin reuptake inhibitors: apropos
of a case].
Schweiz Rundsch Med Prax. 1998 Mar 4;87(10):345-8. Review. French.
PMID: 9545842 [PubMed - indexed for MEDLINE]
Stahl MM, Lindquist M, Pettersson M, Edwards IR, Sanderson JH, Taylor NF,
Fletcher AP, Schou JS.
Withdrawal reactions with selective serotonin re-uptake inhibitors as reported
to the WHO system.
Eur J Clin Pharmacol. 1997;53(3-4):163-9.
PMID: 9476026 [PubMed - indexed for MEDLINE]
Dahl ML, Olhager E, Ahlner J.
Paroxetine withdrawal syndrome in a neonate.
Br J Psychiatry. 1997 Oct;171:391-2. No abstract available.
PMID: 9373435 [PubMed - indexed for MEDLINE]
Zajecka J, Tracy KA, Mitchell S.
Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a
literature review.
J Clin Psychiatry. 1997 Jul;58(7):291-7. Review.
PMID: 9269249 [PubMed - indexed for MEDLINE]
Walker-Kinnear M, McNaughton S.
Paroxetine discontinuation syndrome in association with sertindole therapy.
Br J Psychiatry. 1997 Apr;170:389. No abstract available.
PMID: 9246265 [PubMed - indexed for MEDLINE]
Young AH, Currie A, Ashton CH.
Antidepressant withdrawal syndrome.
Br J Psychiatry. 1997 Mar;170:288. No abstract available.
PMID: 9229040 [PubMed - indexed for MEDLINE]
Landry P, Roy L.
Withdrawal hypomania associated with paroxetine.
J Clin Psychopharmacol. 1997 Feb;17(1):60-1. No abstract available.
PMID: 9004064 [PubMed - indexed for MEDLINE]
Schatzberg AF, Haddad P, Kaplan EM, Lejoyeux M, Rosenbaum JF, Young AH,
Zajecka J.
Possible biological mechanisms of the serotonin reuptake inhibitor
discontinuation syndrome. Discontinuation Consensus Panel.
J Clin Psychiatry. 1997;58 Suppl 7:23-7. Review.
PMID: 9219490 [PubMed - indexed for MEDLINE]
Haddad P.
Newer antidepressants and the discontinuation syndrome.
J Clin Psychiatry. 1997;58 Suppl 7:17-21; discussion 22. Review.
PMID: 9219489 [PubMed - indexed for MEDLINE]
Lejoyeux M, Ades J.
Antidepressant discontinuation: a review of the literature.
J Clin Psychiatry. 1997;58 Suppl 7:11-5; discussion 16. Review.
PMID: 9219488 [PubMed - indexed for MEDLINE]
Price JS, Waller PC, Wood SM, MacKay AV.
A comparison of the post-marketing safety of four selective serotonin re-uptake
inhibitors including the investigation of symptoms occurring on withdrawal.
Br J Clin Pharmacol. 1996 Dec;42(6):757-63.
PMID: 8971432 [PubMed - indexed for MEDLINE]
Arya DK.
Withdrawal after discontinuation of paroxetine.
Aust N Z J Psychiatry. 1996 Oct;30(5):702. No abstract available.
PMID: 8902183 [PubMed - indexed for MEDLINE]
Reeves RR, Pinkofsky HB.
Lhermitte's sign in paroxetine withdrawal.
J Clin Psychopharmacol. 1996 Oct;16(5):411-2. No abstract available.
PMID: 8889917 [PubMed - indexed for MEDLINE]
Coupland NJ, Bell CJ, Potokar JP.
Serotonin reuptake inhibitor withdrawal.
J Clin Psychopharmacol. 1996 Oct;16(5):356-62.
PMID: 8889907 [PubMed - indexed for MEDLINE]
Pacheco L, Malo P, Aragues E, Etxebeste M.
More cases of paroxetine withdrawal syndrome.
Br J Psychiatry. 1996 Sep;169(3):384. No abstract available.
PMID: 8879736 [PubMed - indexed for MEDLINE]
Mareth TR, Brown TM.
SSRI withdrawal.
J Clin Psychiatry. 1996 Jul;57(7):310. No abstract available.
PMID: 8666577 [PubMed - indexed for MEDLINE]
Lazowick AL, Levin GM.
Potential withdrawal syndrome associated with SSRI discontinuation.
Ann Pharmacother. 1995 Dec;29(12):1284-85. No abstract available.
PMID: 8672834 [PubMed - indexed for MEDLINE]
Dominguez RA, Goodnick PJ.
Adverse events after the abrupt discontinuation of paroxetine.
Pharmacotherapy. 1995 Nov-Dec;15(6):778-80.
PMID: 8602387 [PubMed - indexed for MEDLINE]
Fava GA, Grandi S.
Withdrawal syndromes after paroxetine and sertraline discontinuation.
J Clin Psychopharmacol. 1995 Oct;15(5):374-5. No abstract available.
PMID: 8830071 [PubMed - indexed for MEDLINE]
Debattista C, Schatzberg AF.
Physical symptoms associated with paroxetine withdrawal.
Am J Psychiatry. 1995 Aug;152(8):1235-4. No abstract available.
PMID: 7625481 [PubMed - indexed for MEDLINE]
Bloch M, Stager SV, Braun AR, Rubinow DR.
Severe psychiatric symptoms associated with paroxetine withdrawal.
Lancet. 1995 Jul 1;346(8966):57. No abstract available.
PMID: 7603169 [PubMed - indexed for MEDLINE]
Frost L, Lal S.
Shock-like sensations after discontinuation of selective serotonin reuptake
inhibitors.
Am J Psychiatry. 1995 May;152(5):810. No abstract available.
PMID: 7726327 [PubMed - indexed for MEDLINE]
Kreider MS, Bushnell WD, Oakes R, Wheadon DE.
A double-blind, randomized study to provide safety information on switching
fluoxetine-treated patients to paroxetine without an intervening washout period.
J Clin Psychiatry. 1995 Apr;56(4):142-5.
PMID: 7713852 [PubMed - indexed for MEDLINE]
Phillips SD.
A possible paroxetine withdrawal syndrome.
Am J Psychiatry. 1995 Apr;152(4):645-6. No abstract available.
PMID: 7694921 [PubMed - indexed for MEDLINE]
Rafieian-Kopaei M, Gray AM, Spencer PS, Sewell RD.
Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine
withdrawal-induced place conditioning.
Eur J Pharmacol. 1995 Mar 6;275(2):185-9.
PMID: 7796854 [PubMed - indexed for MEDLINE]
Pyke RE.
Paroxetine withdrawal syndrome.
Am J Psychiatry. 1995 Jan;152(1):149-50. No abstract available.
PMID: 7802108 [PubMed - indexed for MEDLINE]
Keuthen NJ, Cyr P, Ricciardi JA, Minichiello WE, Buttolph ML, Jenike MA.
Medication withdrawal symptoms in obsessive-compulsive disorder patients treated
with paroxetine.
J Clin Psychopharmacol. 1994 Jun;14(3):206-7. No abstract available.
PMID: 8027419 [PubMed - indexed for MEDLINE]
Barr LC, Goodman WK, Price LH.
Physical symptoms associated with paroxetine discontinuation.
Am J Psychiatry. 1994 Feb;151(2):289. No abstract available.
PMID: 8296907 [PubMed - indexed for MEDLINE]
Sindrup SH, Gram LF, Brosen K, Eshoj O, Mogensen EF.
The selective serotonin reuptake inhibitor paroxetine is effective in the
treatment of diabetic neuropathy symptoms.
Pain. 1990 Aug;42(2):135-44.
PMID: 2147235 [PubMed - indexed for MEDLINE]
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